Disease Area
Cardiac Biomarker Research
Prevena Health is exploring continuous molecular surveillance of cardiac biomarkers to support earlier awareness of myocardial stress, cardiovascular risk, and heart failure progression.
Our Approach
Continuous cardiac surveillance versus point-in-time testing.
Cardiovascular disease remains a leading cause of mortality worldwide, yet many cardiac events occur without adequate warning. Traditional cardiac biomarker testing relies on point-in-time measurements, often ordered only after symptoms present. This approach may miss subtle, evolving molecular changes that precede acute events.
Prevena Health is developing a platform that aims to enable continuous monitoring of cardiac biomarkers through a wearable sensor and multiplexed assay system. By tracking molecular trends over days and weeks rather than capturing isolated snapshots, our approach is designed to support researchers investigating whether longitudinal biomarker trajectories may provide additional context for cardiovascular risk assessment.
This continuous approach may be particularly relevant for patients with known cardiac risk factors, those recovering from cardiac events, or populations being studied in heart failure research programs.
Key Biomarkers
Molecular markers associated with cardiac stress and injury.
hs-cTnI (High-Sensitivity Cardiac Troponin I)
A highly sensitive marker associated with myocardial injury. Continuous trending of hs-cTnI may reveal subclinical cardiac stress patterns not visible in single-point testing.
hs-cTnT (High-Sensitivity Cardiac Troponin T)
Another cardiac troponin isoform associated with myocardial cell damage. Longitudinal hs-cTnT data is being explored for its potential to support risk stratification research.
NT-proBNP
A natriuretic peptide fragment associated with cardiac wall stress and heart failure. Continuous NT-proBNP monitoring may support research into heart failure progression and decompensation patterns.
BNP (B-Type Natriuretic Peptide)
A hormone released by the heart in response to volume overload and pressure stress. BNP trends may offer temporal context for cardiovascular research programs.
CRP (C-Reactive Protein)
An inflammatory biomarker associated with systemic inflammation and cardiovascular risk. Longitudinal CRP monitoring may provide context for research into inflammatory contributions to cardiac disease.
Galectin-3
A biomarker associated with cardiac fibrosis and remodeling. Galectin-3 trends are being explored for their potential relevance to heart failure research and myocardial tissue change.
Why It Matters
Why continuous cardiac monitoring may change the paradigm.
Cardiovascular disease is the leading global cause of death. Heart disease accounts for a significant proportion of mortality worldwide, yet many events occur in individuals who were not identified as high-risk by conventional testing.
Point-in-time testing may miss evolving risk. A single troponin or BNP measurement captures one moment. Molecular trends over time may reveal patterns of escalating cardiac stress that isolated snapshots cannot.
Heart failure management relies on timely intervention. Research suggests that earlier identification of decompensation signals may support more timely clinical responses. Continuous biomarker data aims to support this type of longitudinal awareness.
Post-event monitoring may benefit from continuity. For patients recovering from myocardial infarction or cardiac procedures, ongoing molecular surveillance may provide clinicians with more complete recovery trajectory data.
Prevena Health's platform is in development and is not commercially available. It has not been cleared, approved, or authorized by the U.S. Food and Drug Administration (FDA) or any other regulatory body. It is not a diagnostic device. Content on this page is for informational purposes only and does not constitute medical advice, diagnosis, or treatment.
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We are seeking cardiology researchers and health systems to explore continuous cardiac molecular surveillance.
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